Changes in chromosome positioning during meiosis and LINC-dependent telocentrosome formation.

<p>(A) Changes in chromosome positioning during meiosis. During mitotic interphase, centromeres (red circles) are located at the SPB, while telomeres (blue circles) are located away from it. When cells enter meiosis by cell conjugation, telomeres cluster at the SPB, which radiates microtubules, and centromeres become detached from it (Karyogamy). After nuclear fusion, the diploid nucleus becomes elongated and oscillates between the cell ends, led by the SPB (Horsetail stage). Thereafter, the nucleus remains in the middle of the cell with several microtubules extending in parallel to the long cell axis until meiotic divisions start (Post-horsetail stage). (B) Factors required for telomere-LINC interaction and telocentrosome formation. γ-TuC: γ-tubulin complex; NE: nuclear envelope.