Regulation of centromere detachment from the SPB and its role in meiosis.

<p>(A) Regulation of centromere detachment from the SPB. Telomere clustering causes SPB recruitment of Taz1, and SPB-recruited Taz1 promotes centromere detachment from the SPB. SPB- and telocentrosome-nucleated microtubules, which drive telomere clustering, also promote centromere detachment. Ndc80C: Ndc80 complex; Mis12C: Mis12 complex. (B) A role of telomere-dependent regulation of centromere detachment in meiosis. During mitosis centromeres are attached to the SPB, while telomeres are located away from it (Rabl). Centromeres become detached from the SPB after clustering of telomeres at the SPB, forming the bouquet chromosome arrangement (Bouquet). When telomere clustering is impaired, the Taz1- and/or microtubule-dependent regulatory mechanism inhibits centromere detachment, preventing concomitant detachment of centromeres and telomeres from the SPB, which is harmful for spindle formation.