Effect of a perinatal HF diet on hypothalamic neuropeptide mRNA expression in Wistar and Lou/C male rats.

<p>A) Schematic representation of the main hypothalamic nuclei implicated in the control of food intake and metabolism. ARC: arcuate nucleus; VMN: ventromedial nucleus; DMN: dorsomedial nucleus; PVN: paraventricular nucleus. Hypothalamic mRNA expression of <i>Pomc</i> (B), <i>Bdnf</i> (C) and <i>Agrp</i> (D) in pSD (n = 3) and pHF Wistar (n = 3–4) and pSD (n = 3) and pHF Lou/C rats (n = 3–6). Values are expressed as percent of pSD Lou/C rats at PND14 (100%) and were normalized with the <i>36b4</i> mRNA expression. E) Hypothalamic mRNA expression of <i>Obrb</i>. Values are expressed as percent of pSD Lou/C rats at PND17 (100%) and were normalized with the <i>36b4</i> mRNA expression. Values are mean ± SEM (n = 3–6). *p<0.05 and ****p<0.0001 using two-way ANOVA.