The effect of 2.5% sevoflurane inhalation on the long-term memory formation.

<p>Mice in the Sevoflurane (n = 16) and Control (n = 16) groups were subjected to PAT, which can evaluate a conditional contextual response related to hippocampus-dependent memory. Acquisition or retention time (sec) defined the latency to enter the dark chamber on day two and the latency to enter it on day three, respectively. The velocity of movement (cm/sec) in the illuminated platform on day two and day three was also evaluated to rule out the effect of sevoflurane on the locomotor activity. The data were expressed as the means ± SD and were analyzed by one-way ANOVA with Scheffe’s test. *: Differences between Sevoflurane and Control groups are statistically significant (P<0.001). The acquisition time (P = 0.319), the velocity of movement on day two (P = 0.281) and day three (P = 0.418) did not differ between the Sevoflurane and Control groups.