KLHDC10 knockout (KO) mice are resistant against TNFα-induced SIRS.

<p>(A) Survival period of WT, KLHDC10 KO, and ASK1 KO mice intravenously injected with 5 μg of mTNFα. (B) Body temperature of WT, KLHDC10 KO, and ASK1 KO mice intravenously injected with 5 μg of mTNFα. Each dot indicates the number of surviving mice at that time point. (C) Body temperature of WT, KLHDC10 KO, and ASK1 KO mice after 0 and 6 hours from the intravenous injection of 5 μg of mTNFα. Data are represented as the mean ± SEM. **<i>P</i><0.01 versus WT mice and *<i>P</i><0.05 versus ASK1 KO mice analyzed by Log-rank test followed with Gehan-Breslow-Wilcoxon test (A). ***<i>P</i><0.001 (blank line) versus WT mice and *<i>P</i><0.05, **<i>P</i><0.01, ***<i>P</i><0.001 (red line) versus ASK1 KO mice. *<i>P</i><0.05 (green line) versus WT mice. All samples were analyzed by two-way ANOVA with the Bonferroni post-hoc test (B). ***<i>P</i><0.001 (blue line) versus WT mice and *<i>P</i><0.05 (green line) versus ASK1 KO mice analyzed by the Student’s <i>t</i> test (C).