Effect of catK deficiency on M1 and M2 macrophage marker expression of non-stimulated BMM.
- Marjo M. P. C. Donners (169445)
- Lili Bai (445878)
- Suzanne P. M. Lutgens (3123921)
- Erwin Wijnands (3123924)
- Jason Johnson (585910)
- Leon J. Schurgers (123737)
- Cong-Lin Liu (3123927)
- Mat J. A. P. Daemen (280608)
- Kitty B. J. M. Cleutjens (134238)
- Guo-Ping Shi (191666)
- Erik A. L. Biessen (132311)
- Sylvia Heeneman (280598)
Publication date
September 2016
DOIAbstract
<p>BMM from wt, catK<sup>-/-</sup>, apoE<sup>-/-</sup> and catK<sup>-/-</sup>//apoE<sup>-/-</sup> mice were isolated and BMM cell lysates were analyzed for M1 and M2 marker expression. CatK<sup>-/-</sup>//apoE<sup>-/-</sup> -derived BMM increased arginase-1 expression (C, P = 0.004) and significantly decreased IL-10 expression (E, P = 0.004) compared with apoE<sup>-/-</sup> -derived-BMM. While IL-18 (A) and Mannose Receptor (D) were not affected, catK deficiency tended to decrease Nos2 expression in ApoE<sup>-/-</sup> BMM (B). Values represent the mean ± SEM. (n = 6 for each group).</p
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