Single cell assays of primary adult B-ALL cells. (A) Each NSI mouse was injected with a single primary B-ALL cell. Sixteen weeks after transplantation, the BM compartments of hosts were subjected to FACS analysis. (B) Representative FACS analysis of B-ALL cells used for single cell transplantation (Before, left) and gated hCD45+ cells from the BM compartments of the successfully grafted hosts (After, right). (JPG 494 kb
Characterization of BMSCs. (A) Morphology of BMSCs at day 12 of culture. Isolated BMSCs grow as fibr...
<p>(A) Phenotypic analysis of light density liver cells pooled from 9 mice harvested 89 days after t...
Figure S1. Expression of CD19/CD20, CD79A/B and RAG1/RAG2 in blood cancer cell lines. X axis: 164 bl...
Reconstitution of adult B-ALL in NSI mice. (A) Left, spleens from of an NSI mouse engrafted with B-A...
Immunophenotypes of the leukemic cells remain stable for serial transplantations. (A) Representative...
Gene expression pattern in subpopulations of B-ALL cells. (A, B) The immunophenotypes of patients #1...
Frequency of CD34+ AML cells is greater in newborn NSG pups than adult NSG mice. Magnetically sorted...
Leukemic cellsâ SNPs are conserved in ex vivo. (A) Whole exome sequencing of the leukemia in xenog...
Myeloid cell reconstitution in spleen and bone marrow. Percentage of myeloid cells (CD33+) in spleen...
Cells expanded on P-MSCs gave rise to persistent engraftment in NOD/SCID mice. a Superior multi-line...
Figure S1. Chemotherapy-induced niche contributes to the increase of ROS and apoptosis in HSCs. (a) ...
Figure S1. Flow cytometry analysis of CD45+CD33+ leukemia cells in peripheral blood of 14 and 7Â day...
© 2016 The Author(s). The existence and identification of leukemia-initiating cells in adult acute ...
Treatment of adult HSCs with NO donor reduces their engraftment ability. The donor cell chimerism in...
BM-MSCs and P-MSCs had similar potential for expansion of CD34+ cells. a BM-MSCs have fibroblastic m...
Characterization of BMSCs. (A) Morphology of BMSCs at day 12 of culture. Isolated BMSCs grow as fibr...
<p>(A) Phenotypic analysis of light density liver cells pooled from 9 mice harvested 89 days after t...
Figure S1. Expression of CD19/CD20, CD79A/B and RAG1/RAG2 in blood cancer cell lines. X axis: 164 bl...
Reconstitution of adult B-ALL in NSI mice. (A) Left, spleens from of an NSI mouse engrafted with B-A...
Immunophenotypes of the leukemic cells remain stable for serial transplantations. (A) Representative...
Gene expression pattern in subpopulations of B-ALL cells. (A, B) The immunophenotypes of patients #1...
Frequency of CD34+ AML cells is greater in newborn NSG pups than adult NSG mice. Magnetically sorted...
Leukemic cellsâ SNPs are conserved in ex vivo. (A) Whole exome sequencing of the leukemia in xenog...
Myeloid cell reconstitution in spleen and bone marrow. Percentage of myeloid cells (CD33+) in spleen...
Cells expanded on P-MSCs gave rise to persistent engraftment in NOD/SCID mice. a Superior multi-line...
Figure S1. Chemotherapy-induced niche contributes to the increase of ROS and apoptosis in HSCs. (a) ...
Figure S1. Flow cytometry analysis of CD45+CD33+ leukemia cells in peripheral blood of 14 and 7Â day...
© 2016 The Author(s). The existence and identification of leukemia-initiating cells in adult acute ...
Treatment of adult HSCs with NO donor reduces their engraftment ability. The donor cell chimerism in...
BM-MSCs and P-MSCs had similar potential for expansion of CD34+ cells. a BM-MSCs have fibroblastic m...
Characterization of BMSCs. (A) Morphology of BMSCs at day 12 of culture. Isolated BMSCs grow as fibr...
<p>(A) Phenotypic analysis of light density liver cells pooled from 9 mice harvested 89 days after t...
Figure S1. Expression of CD19/CD20, CD79A/B and RAG1/RAG2 in blood cancer cell lines. X axis: 164 bl...