Additional file 1: of Is there an added value of faecal calprotectin and haemoglobin in the diagnostic work-up for primary care patients suspected of significant colorectal disease? A cross-sectional diagnostic study

Supplementary appendix. Contents: interaction between POC FIT and overt rectal bleeding; Table S1: model development strategy and specification; Table S2: reclassification table combined POC extended model versus basic diagnostic model; Table S3: reclassification table POC FIT extended model versus basic diagnostic model; Table S4: optimism corrected parameters for the basic model, the calprotectin POC extended model, the calprotectin ELISA extended model, and the calprotectin ELISA and POC FIT extended model; Figure S1: calibration curves; Figure S2: decision curve analysis; Figure S3: ROC curves subsitituting calprotectin POC with ELISA; Figure S4: nomogram of the combined POC extended model; Figure S5: nomogram of the POC FIT extended model. (DOCX 2031 kb