Growth inhibition of HCT-116 and HCT-116/OxR cells xenograft by oxaliplatin.

<p>Nude mice were implanted subcutaneously with cells into flanks on day 0, then treated with or without (as a control) oxaliplatin. (A) Time courses effect of oxaliplatin on the growth of cells xenograft was evaluated by determining the tumor volume every four days. (B) On the 24th day after tumor implantation, the tumor of each mouse was removed and stained with hematoxylin–eosin. The mitosis cells were determined by microscopic examination and counted from 10 fields (200 X magnification) of each tumor sample. Statistical analysis results are the means ± SEM of mitosis cells per microscope field from eight animals per group (n = 8; per group). *P < 0.01, compared with the HCT-116 control group; #P < 0.01, compared with the HCT-116/OxR control group.