IDO-deficient mice are not protected from RSV infection.

<p>MSCs isolated from the leg bones of GFP- mice were infected by human RSV and visualized by fluorescent microscopy (A). RSV infection of wild type (WT) versus IDO knockout (IDO-KO) mice were compared by Plaque forming unit assay (B) and RSV-N gene expression (C). IFN-β expression was examined in the lungs of infected WT and IDO-KO animals (D). RSV- vs mock-infected mouse MSCs were examined for the expression of IFN-β,IDO, NOS2 and RSVN gene (normalized to HPRT) (E). Significance between groups determined by one-way ANOVA with Fisher’s LSD test. Results representative of duplicate experiments. * p < 0.05, *** p < 0.001, ns = non-significant.