Nanosizing a Metal–Organic Framework Enzyme Carrier for Accelerating Nerve Agent Hydrolysis
- Peng Li (69518)
- Su-Young Moon (1454890)
- Mark A. Guelta (2853299)
- Lu Lin (201289)
- Diego A. Gómez-Gualdrón (1635055)
- Randall Q. Snurr (767831)
- Steven P. Harvey (1505965)
- Joseph T. Hupp (1270782)
- Omar K. Farha (1301625)
Publication date
October 2016
DOIAbstract
We report the synthesis and characterization of a water-stable zirconium metal–organic framework (MOF), <b>NU-1003</b>, featuring the largest mesoporous aperture known for a zirconium MOF. This material has been used to immobilize the nerve agent hydrolyzing enzyme, organophosphorus acid anhydrolase (OPAA). The catalytic efficiency of immobilized OPAA in <i>nanosized</i> <b>NU-1003</b> is significantly increased compared to that of OPAA immobilized in <i>microsized</i> <b>NU-1003</b> and even exceeds that of the free OPAA enzyme. This paper highlights a method for rapid and highly efficient hydrolysis of nerve agents using nanosized enzyme carriers
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