Reduced neutrophils in Muc18 KO mice infected with human rhinovirus 1B (HRV-1B).

<p>Muc18 WT (n = 9) and KO (n = 13) were intranasally infected with HRV-1B or PBS as a control (WT: n = 7; KO: n = 7) and sacrificed 24 hours post treatment. Muc18 KO mice had significantly lower levels of neutrophils in bronchoalveolar lavage (BAL) than WT mice. This was seen in both percent neutrophils <b>(A)</b> and in absolute number of neutrophils <b>(B)</b>. <b>(C)</b> HRV infection significantly increased KC levels in WT and KO mice, but there was no significant difference in KC levels between WT and KO mice. Dots represent data from individual of the three independent experiments and the horizontal bars indicate median. The Wilcoxon test was used to compare the difference between groups. A single star (*) indicates p<0.05 and two stars (**) indicates p<0.001.