Increased antiviral gene expression in Muc18 knockout (KO) mice infected with human rhinovirus 1B (HRV-1B).

<p>Muc18 WT (n = 9) and KO (n = 13) were intranasally infected with HRV-1B or PBS as a control (WT: n = 7; KO: n = 7) and sacrificed 24 hours post treatment. In lung tissue, KO mice had significantly higher expression of the antiviral genes Mx1 <b>(A)</b> and IP-10 <b>(B)</b> compared to WT mice. Dots represent data from individual of the three independent experiments and the horizontal bars indicate median. A single star (*) indicates p<0.05 and two stars (**) indicates p<0.001.