Shared genes with variants in the large PC families.

<p>(A) Twenty-two genes in the seven large families remained after filtering and prioritizing. Known susceptibility genes (<i>BRCA2</i> and <i>HOXB13</i>) and one novel gene (<i>TRRAP</i>) are shown by green rectangles. The combined scores of Exomiser are shown on the right side of the gene names. (B) Variant status of <i>BRCA2</i>, <i>HOXB13</i>, and <i>TRRAP</i>. ExAC_all, MAF of all subjects in the ExAC; iJGVD, MAF in the iJGVD; HGVD, MAF in the HGVD; NA, Not applicable. PC, prostate cancer.