Timing and Height of Re-emergent Virus and Viral Reservoirs.

<p>Panel A. presents weeks to re-emergent virus and panel B presents temporal levels of viral RNA throughout the study. Temporal levels of viral RNA are given as medians and interquartile ranges. In panel B, the median pre-ART level of viral RNA is indicated with a square symbol. Panel C shows the frequency of circulating CD4+ T cells harboring integrated HIV DNA. Panel D shows the number of CD4+ cells with inducible Tat/ Rev mRNA as measured by TILDA. Insets in C and D give the medians and interquartile ranges for all participants. Participants are listed in the same order in A, C, and D. Participant 01–7 is not included in reservoir analyses because pre-vaccination cells were not available. Pre designates the day of vaccination and TI-1, the day of treatment interruption. Samples with HIV-1 RNA <50 copies/mL are plotted at 10 copies per ml.