Additional file 1: Figure S1. of DNMT3A mutation leads to leukemic extramedullary infiltration mediated by TWIST1

DNMT3A expression, mutational status in leukemia strains and expression level of DNMT3A in various cell lines. Figure S2. Phenotype evaluations of NOD/SCID mice transplanted with exogenous leukemic cells. Figure S3. Detection of OCI-AML3 cells in the bone marrow (BM) or brain of transplanted mice. Figure S4. Protein levels of DNMT3A and TWIST1 in OCI-AML3 with knockdowned DNMT3A. Figure S5. Proportion of OCI-AML3 cells in mice; expression level of TWIST1 in patient’s cells and constructed cell strains. Figure S6. TWIST1 is essential for OCI-AML3 migration. Figure S7. Compare the methylation level of TWIST1 promoter between patients with WT and mutant DNMT3A. (DOC 3621 kb