LPS exposure results in a significant increase in OLs population without affecting myelination on P21.

<p>A-H: representative micrographs show double-immunostaining of mature OLs (APC+) and total OL lineage cells (Olig2+) in the corpus callosum just above the lateral ventricle. Note a significant increased density of both APC+ and Olig2+ cells in LPS as compared to controls. D and H are high magnification micrographs taken from boxed areas in C and G, respectively. Immunostaining of MBP shows no significant difference in myelination between LPS (J) and the control (I). Cell counting in the corpus callosum showed a significant increase of APC+ mature OLs (K) and Olig2+ total OL lineages (L). *p<0.001 vs control (n = 8).