Anomaly of the urinary tract in the caudal regression syndrome in postnatal rat.

<p><b>(A)</b> View on the kidneys and left ureter <i>in situ</i>: rk—right kidney; lk—left hypoplastic kidney with ureter enormously extended by urine (hydro-ureter). <b>(B)</b> Right kidney with extended pelvis (white arrow) after fixation in Bouin-Hollande fluid, which gives tissues a green colour. <b>(C, D)</b> Comparison between the extended ureter with a large lumen and thin wall in the mutant <b>(C)</b> and a normal urether in wild-type <b>(D)</b> rat. Histological sections of kidney in a wild-type <b>(E-G</b>) and <i>Plzf</i>^<i>-/-</i> <b>(H-J)</b> rat. <b>(E, H)</b> A low magnification shows basic components of kidney: cortex, medulla and renal pelvis (appearing as a free space here), which continues to ureter. Inserted box: A section shows the whole kidney, which has enormously extended pelvis and reduced renal parenchyma in the mutant rat. <b>(F, I)</b> Renal cortex; <b>(G, J)</b> medulla. Black arrow indicates an extended renal pelvis. Single arrowheads—dilated renal tubules with leucocytes. A double arrowhead—renal glomerulus. Bar—1 mm (insert in <b>E</b> and <b>H</b>); 200 μm <b>(C, D, E, H)</b>; 100 μm <b>(F, G, I, J)</b>.