<p>In this study, we investigated the association of mtDNA variants and haplogroups with Type 2 diabetes (T2D) in Moroccan patients. The Hypervariable Segments 1 of the mtDNA was sequenced in 108 diabetic patients and 97 controls. Association analyses were performed using Fisher’s exact test and multivariate logistic regression. The prevalence of five mtDNA variants (C16187T, C16270T, T16172C, A16293G, and C16320T) was significantly higher in cases than in controls. Among these variants, only C16270T (<i>p</i> = .02) and C16320T (<i>p</i> = .03) remains significant after adjusting by age and gender. We showed that C16270T and C16320T variants were strongly associated with increased risk of T2D in Moroccan patients.</p
Mitochondrial dysfunction has been observed in skeletal muscle of people with diabetes and insulin-r...
In this paper, we mine full mtDNA sequences from an exome capture data set of 2000 Danes, showing th...
Mitochondrial DNA (mtDNA) variation has been implicated in many common complex diseases, but inconsi...
The profound impact of mitochondrion in cellular metabolism has been well documented. Since type 2 d...
Mitochondrial dysfunction has been implicated in rare and common forms of type 2 diabetes (T2DM). Ad...
Aims/hypothesis This multinational study was conducted to investigate the association between a mito...
Aims/hypothesis This multinational study was conducted to investigate the association between a mito...
Abstract Background The genetic background of type 2 diabetes is complex involving contribution by b...
Mitochondria play a central role in the secretion of insulin by pancreatic beta-cells, and pathogeni...
AIMS/HYPOTHESIS: This multinational study was conducted to investigate the association between a mit...
Mitochondrial dysfunction has repeatedly been reported associated with type 2 diabetes mellitus (T2D...
The association between mitochondrial DNA (mtDNA) haplogroup and risk of type 2 diabetes (T2D) is un...
Dilated Cardiomyopathy (DCM) is a devastating disease. It is a recognised manifestation of mitochond...
The knowledge of the haplogroups of the analyzed subjects allows to prevent errors in the analysis o...
In this paper, we mine full mtDNA sequences from an exome capture data set of 2000 Danes, showing th...
Mitochondrial dysfunction has been observed in skeletal muscle of people with diabetes and insulin-r...
In this paper, we mine full mtDNA sequences from an exome capture data set of 2000 Danes, showing th...
Mitochondrial DNA (mtDNA) variation has been implicated in many common complex diseases, but inconsi...
The profound impact of mitochondrion in cellular metabolism has been well documented. Since type 2 d...
Mitochondrial dysfunction has been implicated in rare and common forms of type 2 diabetes (T2DM). Ad...
Aims/hypothesis This multinational study was conducted to investigate the association between a mito...
Aims/hypothesis This multinational study was conducted to investigate the association between a mito...
Abstract Background The genetic background of type 2 diabetes is complex involving contribution by b...
Mitochondria play a central role in the secretion of insulin by pancreatic beta-cells, and pathogeni...
AIMS/HYPOTHESIS: This multinational study was conducted to investigate the association between a mit...
Mitochondrial dysfunction has repeatedly been reported associated with type 2 diabetes mellitus (T2D...
The association between mitochondrial DNA (mtDNA) haplogroup and risk of type 2 diabetes (T2D) is un...
Dilated Cardiomyopathy (DCM) is a devastating disease. It is a recognised manifestation of mitochond...
The knowledge of the haplogroups of the analyzed subjects allows to prevent errors in the analysis o...
In this paper, we mine full mtDNA sequences from an exome capture data set of 2000 Danes, showing th...
Mitochondrial dysfunction has been observed in skeletal muscle of people with diabetes and insulin-r...
In this paper, we mine full mtDNA sequences from an exome capture data set of 2000 Danes, showing th...
Mitochondrial DNA (mtDNA) variation has been implicated in many common complex diseases, but inconsi...