Correlations of CSF α-syn, Aβ_1–42, t-tau, and p-tau levels in patients of Parkinson’s disease.

<p>Correlations among cerebrospinal fluid (CSF) α-syn (α-synuclein), amyloid beta 1–42 (Aβ_1–42), total tau (t-tau) and phosphorylated tau 181P (p-tau) in Parkinson disease (PD) participants evaluated at baseline (n = 409). A significant positive correlation was found between CSF levels of α-syn and Aβ _1–42 (A), and tau (B). Because interpretation of α-syn might be confounded by blood contamination of CSF samples, 78 subjects with Hgb levels above the 200 ng/ml were excluded from α-syn analysis. Lines indicate trends within each group as determined by linear regression.