Improvement of glucose tolerance in GK rats by DSC108-Na.

<p>(A) Insulinotropic effect of DSC108-Na in vivo. 30 mg/kg of DSC108-Na was orally administered to GK rats and plasma insulin concentrations were measured. Data are expressed as mean ± SEM (n = 6 for each group). *P < 0.05 (paired <i>t</i> test). (B) Changes in blood glucose levels after oral glucose load following administration of DSC108-Na in GK rats (left). Vehicle or 100 mg/kg of DSC108-Na was orally administered to rats at -20 min, and glucose was orally loaded at 0 min. AUC of glucose is represented in bar graphs (right). Data are expressed as mean ± SEM (n = 6 for each group). Arrow and arrowhead indicate the administration of compound and glucose, respectively. *P < 0.05 (paired <i>t</i> test).