Transcriptional regulation of HRMs.

<p>ChIP assay was performed using antibodies against HIF-α or IgG to confirm the binding of HIF-1 α on the putative HREs in the promoters of specific HRMs. qPCR data showing fold enrichment of bound chromatin compared with input in hMSCs grown in <b>(a)</b> hypoxic or <b>(c)</b> normoxic conditions and hESCs in <b>(b)</b> hypoxic and <b>(d)</b> normoxic conditions. <b>(e)</b> Putative hypoxia signal transduction feedback loop in hESC and hMSCs.