UNC2025 induces cell death in GBM cells.
- Alexandra Sufit (3270084)
- Alisa B. Lee-Sherick (3270075)
- Deborah DeRyckere (182593)
- Manali Rupji (3270081)
- Bhakti Dwivedi (2612152)
- Marileila Varella-Garcia (258433)
- Angela M. Pierce (3270078)
- Jeanne Kowalski (629844)
- Xiaodong Wang (66801)
- Stephen V. Frye (425632)
- H. Shelton Earp (251553)
- Amy K. Keating (3270072)
- Douglas K. Graham (182599)
Publication date
October 2016
DOIAbstract
<p>A172, SF188, and U251 cells were treated with UNC2025 (50nM, 100nM, 200nM), control TKI UNC2369 (200nM), or vehicle (DMSO) for 72 hours. Cells were stained with Po-Pro-1 and propidium iodide and analyzed by flow cytometry to determine apoptotic (Po-Pro-1+/PI-) and dead (PI+) cells. (A) Representative U251 flow cytometry profiles. (B) Mean values and standard errors derived from three independent experiments. (* p<0.5, ** p<0.01, *** p<0.001, 1-sided ANOVA).</p
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