Effect of NGF neutralizing antibody on the ability of pancreatic cancer cells to migrate towards neurites extended from dorsal root ganglia (DRG).

<p>A) Representative images (top panel: bright field; bottom panel: green fluorescence) of the migration of Mia PaCa-2 cells towards nerves treated with different concentrations of NGF neutralizing antibody. Arrows indicate the cancer cells that migrated towards the neurites. B) Quantification of the effect on the migration of cancer cells using relative invasion index. *: p ≤ 0.01; ** ≤ 0.001; *** ≤ 0.0001 (compared to no antibody control).