Stereocontrolled Access to Enantiopure 7‑Substituted <i>cis</i>- and <i>trans</i>-Octahydroindoles

Cyclocondensation of (<i>R</i>)-phenylglycinol with stereoisomeric mixtures (racemates, <i>cis</i>/<i>trans</i>) of 3-substituted 2-oxocyclo­hexane­acetates stereoselectively afforded tricyclic oxazoloindolone lactams, from which straightforward procedures for the stereocontrolled formation of enantiopure 7-substituted octahydro­indoles with a variety of stereochemical patterns have been developed. The methodology has been successfully applied to the synthesis of (+)-α-lycorane