Combined scatter and box-and-whisker plot demonstrating the MS risk score distribution between people with MS and healthy controls.

The Refinement of Genetic Predictors of Multiple Sclerosis

Giulio Disanto
Ruth Dobson
Julia Pakpoor
Ramyiadarsini I. Elangovan
Rocco Adiutori
Jens Kuhle
Gavin Giovannoni

August 2016

A recent genome wide association study (GWAS) demonstrated that more than 100 genetic variants influ...

Single association results of the present tested 58 MS risl loci.

Denis A. Akkad (85208)
Alexandra Olischewsky (745265)
Franziska Reiner (745266)
Kerstin Hellwig (745267)
Sarika Esser (745268)
Jörg T. Epplen (249561)
Tomaz Curk (3421130)
Ralf Gold (42956)
Aiden Haghikia (352973)

May 2015

58 tested MS-risk loci, ranked by p-value for allele frequency comparison between MS patients and...

IgG index (A), QAlb (B) and QIgG (C) values of MS patients and control groups.

Athanasia Mouzaki (151106)
Maria Rodi (789568)
Nikolaos Dimisianos (789569)
Andreas Emmanuil (789570)
Dimitra Kalavrizioti (789571)
Rosa Lagoudaki (390213)
Nikolaos C. Grigoriadis (789572)
Panagiotis Papathanasopoulos (789573)

August 2015

The data are presented as box plots with whiskers, showing the median with the upper (75) and low...

Boxplots of weighted genetic risk score (wGRS) in MS patients and HC considering only HLA-DRB1, HLA-DRB1 + MS associations known in 2011 and HLA-DRB1 + all currently known MS associations.

Giulio Disanto (125817)
Ruth Dobson (179953)
Julia Pakpoor (307549)
Ramyiadarsini I. Elangovan (558729)
Rocco Adiutori (558730)
Jens Kuhle (346208)
Gavin Giovannoni (125820)

May 2014

The wGRS was calculated by multiplying the number of risk alleles by the weight of each SNP an...

Weighted Risk scores for the 6 genotyped SNPs.

Naghmeh Jafari (338267)
Linda Broer (183140)
Cornelia M. van Duijn (103685)
A. Cecile J. W. Janssens (183086)
Rogier Q. Hintzen (159689)

February 2013

The odds ratios for MS are shown according to the number of risk alleles carried. The reference v...

A Risk Score for Predicting Multiple Sclerosis.

Ruth Dobson
Sreeram Ramagopalan
Joanne Topping
Paul Smith
Bhavana Solanky
Klaus Schmierer
Declan Chard
Gavin Giovannoni

January 2016

Multiple sclerosis (MS) develops as a result of environmental influences on the genetically suscepti...

Proportion of population and 95%CIs for each category of risk considering only HLA-DRB1, HLA-DRB1 + MS associations known in 2011 and HLA-DRB1 + all currently known MS associations.

Giulio Disanto (125817)
Ruth Dobson (179953)
Julia Pakpoor (307549)
Ramyiadarsini I. Elangovan (558729)
Rocco Adiutori (558730)
Jens Kuhle (346208)
Gavin Giovannoni (125820)

May 2014

In brief, GWAS statistics (OR and risk allele frequencies) are used to simulate a population of 1...

Delta wGRS.

Denis A. Akkad (85208)
Alexandra Olischewsky (745265)
Franziska Reiner (745266)
Kerstin Hellwig (745267)
Sarika Esser (745268)
Jörg T. Epplen (249561)
Tomaz Curk (3421130)
Ralf Gold (42956)
Aiden Haghikia (352973)

May 2015

Percentage distribution of the ΔwGRS = wGRSMS - wGRScontrols. Th...

A Risk Score for Predicting Multiple Sclerosis

Dobson Ruth
Ramagopalan Sreeram
Topping Joanne
Smith Paul
Solanky Bhavana
Schmierer Klaus
Chard Declan
Giovannoni Gavin

November 2016

Multiple sclerosis (MS) develops as a result of environmental influences on the genetically suscepti...

Distribution of the wGRS in MS patients positive (OCB+) or negative (OCB−) for OCB.

Maurizio A. Leone (283920)
Nadia Barizzone (134711)
Federica Esposito (253042)
Ausiliatrice Lucenti (421504)
Hanne F. Harbo (165753)
An Goris (421505)
Ingrid Kockum (88253)
Annette Bang Oturai (113705)
Elisabeth Gulowsen Celius (306947)
Inger L. Mero (421506)
Bénédicte Dubois (421507)
Tomas Olsson (150960)
Helle Bach Søndergaard (113710)
Daniele Cusi (136954)
Sara Lupoli (188284)
Bettina Kulle Andreassen (385620)
Kjell-Morten Myhr (85218)
Franca R. Guerini (421508)
Giancarlo Comi (223051)
Filippo Martinelli-Boneschi (253045)
Sandra D'Alfonso (191089)

June 2013

wGRS (weighted Genetic Risk Score) has been calculated using the ORs for the 52 non-HLA MS suscep...

CSF cytokine ratios of MS patients and control groups.

Athanasia Mouzaki (151106)
Maria Rodi (789568)
Nikolaos Dimisianos (789569)
Andreas Emmanuil (789570)
Dimitra Kalavrizioti (789571)
Rosa Lagoudaki (390213)
Nikolaos C. Grigoriadis (789572)
Panagiotis Papathanasopoulos (789573)

August 2015

The data are presented as box plots with whiskers, showing the median with the upper (75) and low...

A receiver operating characteristic (ROC) curve generated by the MS risk score when the score of people with MS is compared to that of healthy controls.

Ruth Dobson (179953)
Sreeram Ramagopalan (3253560)
Joanne Topping (461420)
Paul Smith (175833)
Bhavana Solanky (3212784)
Klaus Schmierer (3325206)
Declan Chard (3325203)
Gavin Giovannoni (125820)

November 2016

(a) Including HLA-DRB1*1501 only. (b) Including full genetic information. (c)</b...

The refinement of genetic predictors of multiple sclerosis.

Giulio Disanto
Ruth Dobson
Julia Pakpoor
Ramyiadarsini I Elangovan
Rocco Adiutori
Jens Kuhle
Gavin Giovannoni

A recent genome wide association study (GWAS) demonstrated that more than 100 genetic variants influ...

Box plots of the allelic combinations mean (Plus shape), 25th and 75th percentile (colored box), median (center line in box), range of phenotype (in Whiskers).

Suraj Gurung (636776)
Sujan Mamidi (630183)
J. Michael Bonman (393364)
Mai Xiong (636777)
Gina Brown-Guedira (636778)
Tika B. Adhikari (636779)

September 2014

Box plots of the allelic combinations mean (Plus shape), 25th and 75th percentile (col...

Scatter plot of the association between Multiple Sclerosis Walking Scale-12 (MSWS-12) scores and steps/day in persons with multiple sclerosis.

Robert W. Motl (338954)
Lara A. Pilutti (453840)
Yvonne C. Learmonth (453841)
Myla D. Goldman (453842)
Ted Brown (453843)

September 2013

Scatter plot of the association between Multiple Sclerosis Walking Scale-12 (MSWS-12) scores and ...

The Refinement of Genetic Predictors of Multiple Sclerosis

Giulio Disanto
Ruth Dobson
Julia Pakpoor
Ramyiadarsini I. Elangovan
Rocco Adiutori
Jens Kuhle
Gavin Giovannoni

August 2016

A recent genome wide association study (GWAS) demonstrated that more than 100 genetic variants influ...

Single association results of the present tested 58 MS risl loci.

Denis A. Akkad (85208)
Alexandra Olischewsky (745265)
Franziska Reiner (745266)
Kerstin Hellwig (745267)
Sarika Esser (745268)
Jörg T. Epplen (249561)
Tomaz Curk (3421130)
Ralf Gold (42956)
Aiden Haghikia (352973)

May 2015

58 tested MS-risk loci, ranked by p-value for allele frequency comparison between MS patients and...

IgG index (A), QAlb (B) and QIgG (C) values of MS patients and control groups.

Athanasia Mouzaki (151106)
Maria Rodi (789568)
Nikolaos Dimisianos (789569)
Andreas Emmanuil (789570)
Dimitra Kalavrizioti (789571)
Rosa Lagoudaki (390213)
Nikolaos C. Grigoriadis (789572)
Panagiotis Papathanasopoulos (789573)

August 2015

The data are presented as box plots with whiskers, showing the median with the upper (75) and low...

Boxplots of weighted genetic risk score (wGRS) in MS patients and HC considering only HLA-DRB1, HLA-DRB1 + MS associations known in 2011 and HLA-DRB1 + all currently known MS associations.

Giulio Disanto (125817)
Ruth Dobson (179953)
Julia Pakpoor (307549)
Ramyiadarsini I. Elangovan (558729)
Rocco Adiutori (558730)
Jens Kuhle (346208)
Gavin Giovannoni (125820)

May 2014

The wGRS was calculated by multiplying the number of risk alleles by the weight of each SNP an...

Weighted Risk scores for the 6 genotyped SNPs.

Naghmeh Jafari (338267)
Linda Broer (183140)
Cornelia M. van Duijn (103685)
A. Cecile J. W. Janssens (183086)
Rogier Q. Hintzen (159689)

February 2013

The odds ratios for MS are shown according to the number of risk alleles carried. The reference v...

A Risk Score for Predicting Multiple Sclerosis.

Ruth Dobson
Sreeram Ramagopalan
Joanne Topping
Paul Smith
Bhavana Solanky
Klaus Schmierer
Declan Chard
Gavin Giovannoni

January 2016

Multiple sclerosis (MS) develops as a result of environmental influences on the genetically suscepti...

Proportion of population and 95%CIs for each category of risk considering only HLA-DRB1, HLA-DRB1 + MS associations known in 2011 and HLA-DRB1 + all currently known MS associations.

Giulio Disanto (125817)
Ruth Dobson (179953)
Julia Pakpoor (307549)
Ramyiadarsini I. Elangovan (558729)
Rocco Adiutori (558730)
Jens Kuhle (346208)
Gavin Giovannoni (125820)

May 2014

In brief, GWAS statistics (OR and risk allele frequencies) are used to simulate a population of 1...

Delta wGRS.

Denis A. Akkad (85208)
Alexandra Olischewsky (745265)
Franziska Reiner (745266)
Kerstin Hellwig (745267)
Sarika Esser (745268)
Jörg T. Epplen (249561)
Tomaz Curk (3421130)
Ralf Gold (42956)
Aiden Haghikia (352973)

May 2015

Percentage distribution of the ΔwGRS = wGRSMS - wGRScontrols. Th...

A Risk Score for Predicting Multiple Sclerosis

Dobson Ruth
Ramagopalan Sreeram
Topping Joanne
Smith Paul
Solanky Bhavana
Schmierer Klaus
Chard Declan
Giovannoni Gavin

November 2016

Multiple sclerosis (MS) develops as a result of environmental influences on the genetically suscepti...

Distribution of the wGRS in MS patients positive (OCB+) or negative (OCB−) for OCB.

Maurizio A. Leone (283920)
Nadia Barizzone (134711)
Federica Esposito (253042)
Ausiliatrice Lucenti (421504)
Hanne F. Harbo (165753)
An Goris (421505)
Ingrid Kockum (88253)
Annette Bang Oturai (113705)
Elisabeth Gulowsen Celius (306947)
Inger L. Mero (421506)
Bénédicte Dubois (421507)
Tomas Olsson (150960)
Helle Bach Søndergaard (113710)
Daniele Cusi (136954)
Sara Lupoli (188284)
Bettina Kulle Andreassen (385620)
Kjell-Morten Myhr (85218)
Franca R. Guerini (421508)
Giancarlo Comi (223051)
Filippo Martinelli-Boneschi (253045)
Sandra D'Alfonso (191089)

June 2013

wGRS (weighted Genetic Risk Score) has been calculated using the ORs for the 52 non-HLA MS suscep...

CSF cytokine ratios of MS patients and control groups.

Athanasia Mouzaki (151106)
Maria Rodi (789568)
Nikolaos Dimisianos (789569)
Andreas Emmanuil (789570)
Dimitra Kalavrizioti (789571)
Rosa Lagoudaki (390213)
Nikolaos C. Grigoriadis (789572)
Panagiotis Papathanasopoulos (789573)

August 2015

The data are presented as box plots with whiskers, showing the median with the upper (75) and low...

A receiver operating characteristic (ROC) curve generated by the MS risk score when the score of people with MS is compared to that of healthy controls.

Ruth Dobson (179953)
Sreeram Ramagopalan (3253560)
Joanne Topping (461420)
Paul Smith (175833)
Bhavana Solanky (3212784)
Klaus Schmierer (3325206)
Declan Chard (3325203)
Gavin Giovannoni (125820)

November 2016

(a) Including HLA-DRB1*1501 only. (b) Including full genetic information. (c)</b...

The refinement of genetic predictors of multiple sclerosis.

Giulio Disanto
Ruth Dobson
Julia Pakpoor
Ramyiadarsini I Elangovan
Rocco Adiutori
Jens Kuhle
Gavin Giovannoni

A recent genome wide association study (GWAS) demonstrated that more than 100 genetic variants influ...

Box plots of the allelic combinations mean (Plus shape), 25th and 75th percentile (colored box), median (center line in box), range of phenotype (in Whiskers).

Suraj Gurung (636776)
Sujan Mamidi (630183)
J. Michael Bonman (393364)
Mai Xiong (636777)
Gina Brown-Guedira (636778)
Tika B. Adhikari (636779)

September 2014

Box plots of the allelic combinations mean (Plus shape), 25th and 75th percentile (col...

Scatter plot of the association between Multiple Sclerosis Walking Scale-12 (MSWS-12) scores and steps/day in persons with multiple sclerosis.

Robert W. Motl (338954)
Lara A. Pilutti (453840)
Yvonne C. Learmonth (453841)
Myla D. Goldman (453842)
Ted Brown (453843)

September 2013

Scatter plot of the association between Multiple Sclerosis Walking Scale-12 (MSWS-12) scores and ...

The Refinement of Genetic Predictors of Multiple Sclerosis

Giulio Disanto
Ruth Dobson
Julia Pakpoor
Ramyiadarsini I. Elangovan
Rocco Adiutori
Jens Kuhle
Gavin Giovannoni

August 2016

A recent genome wide association study (GWAS) demonstrated that more than 100 genetic variants influ...

Single association results of the present tested 58 MS risl loci.

Denis A. Akkad (85208)
Alexandra Olischewsky (745265)
Franziska Reiner (745266)
Kerstin Hellwig (745267)
Sarika Esser (745268)
Jörg T. Epplen (249561)
Tomaz Curk (3421130)
Ralf Gold (42956)
Aiden Haghikia (352973)

May 2015

58 tested MS-risk loci, ranked by p-value for allele frequency comparison between MS patients and...

IgG index (A), QAlb (B) and QIgG (C) values of MS patients and control groups.

Athanasia Mouzaki (151106)
Maria Rodi (789568)
Nikolaos Dimisianos (789569)
Andreas Emmanuil (789570)
Dimitra Kalavrizioti (789571)
Rosa Lagoudaki (390213)
Nikolaos C. Grigoriadis (789572)
Panagiotis Papathanasopoulos (789573)

August 2015

The data are presented as box plots with whiskers, showing the median with the upper (75) and low...

Combined scatter and box-and-whisker plot demonstrating the MS risk score distribution between people with MS and healthy controls.

Abstract

Extracted data

Combined scatter and box-and-whisker plot demonstrating the MS risk score distribution between people with MS and healthy controls.

Abstract

Extracted data

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