Effect of adipose-derived stem cells (ASCs) on the expression of IDO, TGF-β, and PGE2.

<p>ASCs (A) or ASCs derived from indoleamine 2, 3-dioxygenase (IDO)-knockout (KO) mice (B) treatment significantly increased TGF-β expression in lung tissue and PGE2 levels in the serum of asthmatic mice. However, IDO expression in lung tissue was increased in the OVA+ASC group of WT asthmatic mice, but not in the OVA+ASC group of IDO-KO asthmatic mice and OVA+IDO-KO ASC group. Data are expressed as the mean ± SEM of four independent experiments performed in triplicate. _* <i>p</i><0.05, _** <i>p</i>≤0.005, _*** <i>p</i>≤0.001.