Additional file 10: Figure S4. of Stringent comparative sequence analysis reveals SOX10 as a putative inhibitor of glial cell differentiation

SOX10 regulates genes that inhibit glial cell differentiation in vivo. Primary Schwann cells were extracted and grown from three independent rat adult sciatic nerves. Cells were treated with a control siRNA or an siRNA targeted against Sox10 as in Fig. 7c. Quantitative RT-PCR was used to measure expression levels of each indicated gene. The effect on expression of each gene (indicated across the bottom) is expressed relative to the control siRNA and error bars indicate standard deviations. Please note that, consistent with the in vitro data, Hmga2 did not show a decrease in expression levels in vivo (data not shown). (PDF 334 kb