Average tumor values of DCE-MRI derived parameters at different time points before and after PDT, for treated and non-treated animals.

<p>Based on independent <i>t</i>-tests, average non-enhanced tumor fractions were significantly different between treated and non-treated animals right after, and 24 and 72 h after PDT (all: <i>p</i> < 0.0005). For all time points after PDT, the repeated measurements difference of treated animals compared to before PDT was significant (all: <i>p</i> < 0.0005), while this was not the case for controls. Directly after PDT, the average tumor K^trans decreased and v_e increased significantly compared to baseline based on repeated measures (both: <i>p</i> < 0.0001), and also compared to untreated animals at the same time point (<i>p</i> < 0.0001 and <i>p</i> = 0.038, respectively).