CCL2 production associated with MMTV-neu-driven tumors.
- Xuguang Chen (3335493)
- Yunyue Wang (369039)
- David Nelson (302089)
- Sara Tian (3335490)
- Erin Mulvey (769770)
- Bhumi Patel (173812)
- Ilaria Conti (836356)
- Juan Jaen (3235182)
- Barrett J. Rollins (421839)
Publication date
November 2016
DOIAbstract
<p>(<b>A</b>) CCL2 concentrations were measured by ELISA in sera from 4 wild type and 6 <i>neu</i><sup><i>+</i></sup> mice at the indicated ages. The difference between wild type and tumor bearing mice was significant by two-way ANOVA (p < 0.05). (<b>B</b>) Cell lines were developed from <i>neu</i><sup><i>+</i></sup>, <i>neu</i><sup><i>+</i></sup>/<i>CCL2</i><sup><i>-/-</i></sup>, and <i>neu</i><sup><i>+</i></sup>/<i>CCR2</i><sup><i>-/-</i></sup> mice. CCL2 released into the culture medium by 10<sup>6</sup> cells over a 72 hr period was measured by ELISA.</p
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