Tp0624 amino acid sequence-based modularity analysis.

<p>Orthologs of Tp0624 were identified using BLASTp. Tp0624 signal peptide (SP), domains (D1, green; D2, cyan; D3, purple), and linkers (L1 and L2, yellow) are shown. Indicated on the right are the numbers of orthologs with different domain combinations from spirochetes (left number) or other bacteria (right number). Sequences homologous to D1 and D2 only occur together, while D3 homologs are ubiquitous, and all three domains only occur together in treponemes (shown by an asterisk).