The Effect of a Novel Highly Selective Inhibitor of the Sodium/Calcium Exchanger (NCX) on Cardiac Arrhythmias in <i>In Vitro</i> and <i>In Vivo</i> Experiments - Fig 4

<p><b>Panel A.</b> Lack of effect of 1 μM ORM-10962 on the L-type I_Ca in dog ventricular myocytes. The panel illustrates original I_CaL current traces before and after application of 1 μM ORM-10962 (left panel) and the corresponding current-voltage relationship of I_CaL in the absence and presence of 1 μM ORM-10962, as well as after washout of ORM-10962 on an average of 7 myocytes. Values are means ± standard errors of the means, n = 7, *p<0.05. Insets show the applied voltage protocols. <b>Panel B.</b> Lack of significant effect of ORM-10962 on slow response action potentials in guinea-pig ventricular myocytes. Original slow action potential records under control conditions, in the presence of 1 μM ORM-10962 and after application of 100 nM nisoldipine (<i>left</i>). Bar diagrams (<i>right</i>) reveal the lack of effect of 1 μM ORM-10962 on the action potential amplitude and on the maximum rate of depolarization (dV/dt_max), respectively. Values are means ± SEM, n = 5. *P<0.05.