Heparin displaces siRNA from its binding to PLL dendrons.

<p>Dendriplexes were formed at a dendron/siRNA molar ratio of 30 being the siRNA concentration 100 nM. Following the dendriplex formation, siRNA was displaced from the dendrons by incubation with increasing heparin concentrations (0.01 to 0.5 USP units) and the samples run on a 1.2% agarose gel as indicated in Material and Methods. Panels show an experiment repeated twice with similar results. The panels represent the data for (A) F4, (B) F11; (C) F6 and (D) F15 dendrons.