SMN mRNA transcript levels in blood and fibroblasts from patients with SMA in relation to age.
- Renske I. Wadman (3366548)
- Marloes Stam (3366551)
- Marc D. Jansen (596869)
- Yana van der Weegen (3366536)
- Camiel A. Wijngaarde (3366554)
- Oliver Harschnitz (3366539)
- Peter Sodaar (3366545)
- Kees P. J. Braun (397362)
- Dennis Dooijes (119429)
- Henny H. Lemmink (3366542)
- Leonard H. van den Berg (119440)
- W. Ludo van der Pol (3366557)
Publication date
November 2016
DOIAbstract
<p>(A) SMN2 mRNA expression levels in blood from patients with SMA. SMN2-Δ7 levels were significantly higher than SMN2-FL levels. SMN2-FL and SMN2-Δ7 levels in blood did not correlate with age (p = 0.35). (B) SMN2 mRNA expression levels in fibroblasts in patients with SMA. SMN2-Δ7 levels were significantly higher than SMN2-FL levels. Data shown are normalized to geometric mean (= GM) of GAPDH- and 18S-reference genes. SMN2-D7 = SMN2-Δ7.</p
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