Infectivity of the different strains in THP-1-derived macrophages and intracellular drug resistance.

<p><b>(A)</b> Infectivity of the different studied strains after 96h post-infection in the absence of drug treatment. The P_Idx represents the percentage of infected cells multiplied by the mean number of parasites per cell. Histogram showing normalized P_Idx dose-response effect after 96 h of exposition to increasing concentrations of AmB <b>(B)</b> and MF <b>(C)</b> for the strains studied in (A). Normalization represents the percent reduction of the total parasite burden compared to the non-treated infected control. Data are the mean ± S.D. of two independent experiments run in triplicate. Statistical significance between the mock-transfected wild-type and the rest of the strains was evaluated by unpaired two-tailed t test (*<i>p ≤ 0</i>.<i>05</i>, **<i>p ≤ 0</i>.<i>01</i>, ***<i>p ≤ 0</i>.<i>001</i>).