Internal validity score of applications depending on the species of animals.

<p>(A) Boxplot of the IVS for the five categories of animal species (CDRP: cats, dogs, rabbits and, primates; Farm: farm animals; O_mamm: other mammals; Rodents: laboratory rodents; N_mamm: non-mammals). The dashed blue line represents the overall mean IVS for the entire sample. The red squares represent the mean IVS for each category of animal species. (B–E) Barplots (with binomial confidence intervals) representing the reporting rates for each category of species (C: cats, dogs, rabbits and, primates; F: farm animals; O: other mammals; R: laboratory rodents; N: non-mammals) for blinding (B), randomization (C), sample size calculation (D), and statistical analysis (E). Individual data are shown in <a href="https://figshare.com/s/bc48ed5dff9e6ebd2000" target="_blank">https://figshare.com/s/bc48ed5dff9e6ebd2000</a> (Figure 4).