Ru-Catalyzed One-Pot Diannulation of Heteroaryls: Direct Access to π‑Conjugated Polycyclic Amides

A novel Ru-catalyzed oxidative double annulation of heteroarenes with symmetrical and unsymmetrical alkynes is reported. A general method for the unsymmetrical annulation of heteroarenes with two distinct alkynes is showcased for the first time. Methylphenyl sulfoximine (MPS) plays an important role in the annulations of heteroarenes and allows the construction of structurally complex π-conjugated heteroarene-fused polycyclic amide skeletons via the formation of multiple C–C and C–N bonds in a single operation. The reaction exhibits excellent substrate scope and tolerates a wide range of functional groups