MOESM1 of Cytochrome P450 2D-mediated metabolism is not necessary for tafenoquine and primaquine to eradicate the erythrocytic stages of Plasmodium berghei

Additional file 1. Figure S1. Primaquine causal prophylactic (hepatic) IVIS activity (refer to manuscript Table 2). Figure S2 (Part 1/2 and Part 2/2): Tafenoquine causal prophylactic (hepatic) IVIS activity (refer to manuscript Table 3). Figure S3. Comparison of IVIS vehicle control wild-type (WT) and CYP2D knock-out (KO) C57BL mice. Figure S4. Individual IVIS bioluminescence signal values measured in C57BL/6 WT and CYP2D KO mice. Figure S5. Forrest Plot of percent parasitaemia following 40mpk PQ or 25mpk TQ administered day 4 post IV sporozoite challenge (day 0). Figure S6. Forrest Plot of percent gametocytaemia (mature gametocytes) following 40mpk PQ or 25mpk TQ administered day 4 post IV sporozoite challenge. Figure S7. Correlation between flow cytometry and light microscopy (based upon percent parasitaemia). Solid line represents linear regression. Figure S8. Genetic verification of a subset of C57BL wild-type and CYP2D knock-out mice