Additional file 3: Figure S3. of Tollip, an early regulator of the acute inflammatory response in the substantia nigra

LPS induces a dose-dependent increase of the pro-inflammatory cytokines IL-1β, IL-6, and TNF-α 6 h after injection. WT mice underwent PBS or LPS (0.01 or 0.1 or 1 μg) injection (n = 3 mice per group). mRNA amounts in midbrain extracts are normalized by β-actin and GAPDH. Results are expressed as mean ± SEM, *P < 0.05 versus PBS group, using a Kruskal–Wallis test followed by a Dunn’s post hoc test. (TIF 1059 kb