<p>Leukocytes of wild-type (WT) C57BL/6, CCR2<sup>-/-</sup>, CCR2<sup>-/-</sup>→WT and WT→CCR2<sup>-/-</sup> mice were analysed in brain homogenates by flow cytometry prior to (day 0) and on days 4, 6, 8 and 10 following intranasal infection with 1.2x10<sup>6</sup> PFU of HSV-1. <b>(A)</b> Flow cytometry contour plots illustrating the gating strategy used for brain leukocytes differentiation in mouse sacrificed on day 6 following infection. The CD45 marker was used to discriminate microglia (i.e., CD45<sup>low</sup>; continuous rectangle) from infiltrating leukocytes (i.e., CD45<sup>hi</sup>; dashed rectangle). Among «CD45<sup>hi</sup>/CD11b<sup>+</sup>» infiltrating myeloid cells (dashed circle), monocytes subsets were discriminated accord...
The CC chemokine ligand 2 (CCL2, monocyte chemoattractant protein-1) is important in coordinating th...
<p>(A) Brain sections of infected GFP<sup>+/-</sup>→WT mice were stained for microglial cells with r...
<p><i>A</i>: Brain sequestered leukocytes (BSLs) purified from perfused brain tissue of moribund mic...
<p>Wild-type (WT) C57BL/6, CCR2<sup>-/-</sup>, CCR2<sup>-/-</sup>→WT and WT→CCR2<sup>-/-</sup> mice ...
<p>Levels of cytokines and chemokines in brain homogenates of wild-type (WT) C57BL/6, CCR2<sup>-/-</...
<p>Eight-week old recipient wild-type (WT) C57BL/6 and CCR2<sup>-/-</sup> mice conditioned with irra...
<p>Kinetics of cell infiltration into the brain of 8-week-old CCR5<sup>+/+</sup> and CCR5<sup>−/−</s...
CC chemokine receptor 2 (CCR2) is a prominent receptor for the monocyte chemoattractant protein (MCP...
Monocyte subpopulations distinguished by differential expression of chemokine receptors CCR2 and CX3...
<p>The frequency (<b>A</b>) and overall number (<b>B</b>) of Ly6C<sup>hi</sup> monocytes in the bloo...
, partly due to lack of CCR2 reagents. cells in the central nervous system of these mice. CCR2-RFP e...
In traumatic brain injury (TBI), a diversity of brain resident and peripherally derived myeloid cell...
<p>(A) The percentage of CD11c<sup>+</sup> cells expressing CCR7 was determined by flow cytometry in...
<p>Total leukocytes (CD45 events) were gated for CD45 and either Cd11b/c or CD11b expressions and fu...
<p>C57BL/6 wild-type (WT) or CCR2 knock-out (KO) mice were exposed to room air (open bars) or cigare...
The CC chemokine ligand 2 (CCL2, monocyte chemoattractant protein-1) is important in coordinating th...
<p>(A) Brain sections of infected GFP<sup>+/-</sup>→WT mice were stained for microglial cells with r...
<p><i>A</i>: Brain sequestered leukocytes (BSLs) purified from perfused brain tissue of moribund mic...
<p>Wild-type (WT) C57BL/6, CCR2<sup>-/-</sup>, CCR2<sup>-/-</sup>→WT and WT→CCR2<sup>-/-</sup> mice ...
<p>Levels of cytokines and chemokines in brain homogenates of wild-type (WT) C57BL/6, CCR2<sup>-/-</...
<p>Eight-week old recipient wild-type (WT) C57BL/6 and CCR2<sup>-/-</sup> mice conditioned with irra...
<p>Kinetics of cell infiltration into the brain of 8-week-old CCR5<sup>+/+</sup> and CCR5<sup>−/−</s...
CC chemokine receptor 2 (CCR2) is a prominent receptor for the monocyte chemoattractant protein (MCP...
Monocyte subpopulations distinguished by differential expression of chemokine receptors CCR2 and CX3...
<p>The frequency (<b>A</b>) and overall number (<b>B</b>) of Ly6C<sup>hi</sup> monocytes in the bloo...
, partly due to lack of CCR2 reagents. cells in the central nervous system of these mice. CCR2-RFP e...
In traumatic brain injury (TBI), a diversity of brain resident and peripherally derived myeloid cell...
<p>(A) The percentage of CD11c<sup>+</sup> cells expressing CCR7 was determined by flow cytometry in...
<p>Total leukocytes (CD45 events) were gated for CD45 and either Cd11b/c or CD11b expressions and fu...
<p>C57BL/6 wild-type (WT) or CCR2 knock-out (KO) mice were exposed to room air (open bars) or cigare...
The CC chemokine ligand 2 (CCL2, monocyte chemoattractant protein-1) is important in coordinating th...
<p>(A) Brain sections of infected GFP<sup>+/-</sup>→WT mice were stained for microglial cells with r...
<p><i>A</i>: Brain sequestered leukocytes (BSLs) purified from perfused brain tissue of moribund mic...