<p>The icons represent the sixteen regulated proteins in our model of the budding yeast cell cycle. (The seventeenth component is a generic phosphatase, Hbf, that is synthesized and degraded constitutively but fluctuates nonetheless in the stochastic version of the model.) In this “influence diagram” the barbed arrows and blunt-headed lines represent positive and negative influences, respectively. Mechanistic details of the model are given in <b>Figures A-F</b> in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1005230#pcbi.1005230.s001" target="_blank">S1 Text</a>.</p
<p>Nodes with states ON/OFF represent the presence of proteins. Arrows represent interactions betwee...
In order for the cell's genome to be passed intact from one generation to the next, the events of th...
The operating principles of complex regulatory networks are more easily understood with mathematical...
This is a diagram of the cell cycle of budding yeast. The diagram is based on a figure from:Tyson, J...
<p>Arrow-headed dashed lines indicate positive transcriptional regulation, arrow-headed solid lines—...
To understand the molecular mechanisms that regulate cell cycle progression in eukaryotes, a variety...
<p>The ellipses are proteins; the rectangles are genes; and the triangles are metabolites. The linka...
<p>(A) The network structure of the yeast cell cycle, where <i>x</i>, <i>y</i> and <i>z</i> represen...
Cell cycle is the central process that regulates growth and division in all eukaryotes. Based on the...
Abstract: Proteins involved in the regulation of the cell cycle are highly conserved across all euka...
<p>Green arrows denote activations, whereas red T-ended edges denote inhibitions. In Li <i>et al.</i...
AbstractWe propose a protein interaction network for the regulation of DNA synthesis and mitosis tha...
In the living cells, molecules including proteins, DNAs, RNAs and so on, with interactions between t...
<p>Network model of the fission yeast cell-cycle regulation. Nodes denote threshold functions (1), r...
The eukaryotic cell cycle is robustly designed, with interacting molecules organized within a defini...
<p>Nodes with states ON/OFF represent the presence of proteins. Arrows represent interactions betwee...
In order for the cell's genome to be passed intact from one generation to the next, the events of th...
The operating principles of complex regulatory networks are more easily understood with mathematical...
This is a diagram of the cell cycle of budding yeast. The diagram is based on a figure from:Tyson, J...
<p>Arrow-headed dashed lines indicate positive transcriptional regulation, arrow-headed solid lines—...
To understand the molecular mechanisms that regulate cell cycle progression in eukaryotes, a variety...
<p>The ellipses are proteins; the rectangles are genes; and the triangles are metabolites. The linka...
<p>(A) The network structure of the yeast cell cycle, where <i>x</i>, <i>y</i> and <i>z</i> represen...
Cell cycle is the central process that regulates growth and division in all eukaryotes. Based on the...
Abstract: Proteins involved in the regulation of the cell cycle are highly conserved across all euka...
<p>Green arrows denote activations, whereas red T-ended edges denote inhibitions. In Li <i>et al.</i...
AbstractWe propose a protein interaction network for the regulation of DNA synthesis and mitosis tha...
In the living cells, molecules including proteins, DNAs, RNAs and so on, with interactions between t...
<p>Network model of the fission yeast cell-cycle regulation. Nodes denote threshold functions (1), r...
The eukaryotic cell cycle is robustly designed, with interacting molecules organized within a defini...
<p>Nodes with states ON/OFF represent the presence of proteins. Arrows represent interactions betwee...
In order for the cell's genome to be passed intact from one generation to the next, the events of th...
The operating principles of complex regulatory networks are more easily understood with mathematical...