Working Model.
- Nidhi Jalan-Sakrikar (1347150)
- Thiago M. De Assuncao (3391997)
- Jie Lu (139953)
- Luciana L. Almada (119627)
- Gwen Lomberk (23718)
- Martin E. Fernandez-Zapico (119657)
- Raul Urrutia (1537)
- Robert C. Huebert (3392000)
Publication date
December 2016
DOIAbstract
<p>An epigenetic program, initiated by Shh, and mediated by EZH2 loss, links cholangiocyte maturation to the deposition of a provisional FN matrix, shedding light on the simultaneous processes of biliary repair and peri-portal scar formation. FN may serve as a provisional scaffold for subsequent recruitment and activation of hepatic stellate cells or portal myofibroblasts.</p
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