Schematic models of evolutionary progression in transformed and progressed follicular lymphoma.

<p>(A) The timesweep facet (top) shows the diagram of a prototypical transformed case in follicular lymphoma, indicating dynamics of clonal composition from germline to diagnostic T1 specimen to histologically transformed T2 specimen. The clonal trajectory facet (bottom) presents an alternative view of the timesweep facet, without the clonal hierarchy, demonstrating the trajectory of the individual clones over time. Listed genes include those found to be predominantly enriched at one time point in our study and/or in the literature. (B) The timesweep facet (top) shows the diagram of a prototypical follicular lymphoma case that progressed on treatment, indicating dynamics of clonal composition from germline to diagnostic T1 specimen to progressed T2 specimen, with the trajectory of each clone presented in the clonal trajectory facet (bottom).