<p>Data contains copy number data from non-TCGA projects [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1006436#pgen.1006436.ref014" target="_blank">14</a>] and data generated by the Broad Institute TCGA Genome Characterization Center of the GISTIC portal. The blue bars (left <i>y-</i>axis) are Q-values (–Log10), representing that the gene inside the locus significantly enriched for deletion because of selective pressures. Highly deleted genes imply their role as tumor suppressors. The red dots (right <i>y</i>-axis) are the number of genes inside the peak. Numbers under CFS genes emphasize that these are unique within their peak.</p
<p>Genes that are known to be associated with cancer (black) and all remaining genes (gray) were gro...
A powerful way to discover key genes playing causal roles in oncogenesis is to identify genomic regi...
The landscape of somatic acquired deletions in cancer cells is shaped by positive and negative selec...
<p>Scatter dot plots of values for statistics that distinguish focal deletions affecting common frag...
<p>(A) Average DNA segment size as a function of position on chromosome 1 is displayed. (B) the 9,40...
One of the key questions about genomic alterations in cancer is whether they are functional in the s...
<p>Genes that had 15 or more focal deletions (4,823) were analyzed by the unsupervised learning meth...
One of the key questions about genomic alterations in cancer is whether they are functional in the s...
SummaryCancer genomes exhibit numerous deletions, some of which inactivate tumor suppressor genes an...
One of the key questions about genomic alterations in cancer is whether they are functional in the s...
<p>From the initial list of 461 genes amplified in one or more TCGA datasets, 73 amplified genes wer...
<p>(A) The frequency with which the indicated common fragile site or CFS-like gene is deleted in dif...
A) Schematic shows the steps involved in shortlisting genes from the individual TCGA cancer dataset ...
<p>Genomic and gene expression profiles were established for 188 breast tumors (32 luminal B and 156...
The cancer genome is moulded by the dual processes of somatic mutation and selection. Homozygous del...
<p>Genes that are known to be associated with cancer (black) and all remaining genes (gray) were gro...
A powerful way to discover key genes playing causal roles in oncogenesis is to identify genomic regi...
The landscape of somatic acquired deletions in cancer cells is shaped by positive and negative selec...
<p>Scatter dot plots of values for statistics that distinguish focal deletions affecting common frag...
<p>(A) Average DNA segment size as a function of position on chromosome 1 is displayed. (B) the 9,40...
One of the key questions about genomic alterations in cancer is whether they are functional in the s...
<p>Genes that had 15 or more focal deletions (4,823) were analyzed by the unsupervised learning meth...
One of the key questions about genomic alterations in cancer is whether they are functional in the s...
SummaryCancer genomes exhibit numerous deletions, some of which inactivate tumor suppressor genes an...
One of the key questions about genomic alterations in cancer is whether they are functional in the s...
<p>From the initial list of 461 genes amplified in one or more TCGA datasets, 73 amplified genes wer...
<p>(A) The frequency with which the indicated common fragile site or CFS-like gene is deleted in dif...
A) Schematic shows the steps involved in shortlisting genes from the individual TCGA cancer dataset ...
<p>Genomic and gene expression profiles were established for 188 breast tumors (32 luminal B and 156...
The cancer genome is moulded by the dual processes of somatic mutation and selection. Homozygous del...
<p>Genes that are known to be associated with cancer (black) and all remaining genes (gray) were gro...
A powerful way to discover key genes playing causal roles in oncogenesis is to identify genomic regi...
The landscape of somatic acquired deletions in cancer cells is shaped by positive and negative selec...