Two pathways, Ras-Raf-MEK-ERK and PI3K-AKT lead to the cell proliferation.
- Xiulan Lai (494041)
- Avner Friedman (54903)
Publication date
December 2016
DOIAbstract
<p>Sharp arrows indicate activation/enhancement and blocked arrows indicate inhibition.</p
<p>Sharp arrows indicate activation/enhancement and blocked arrows indicate inhibition.</p
The Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades are often activated by genetic alterations in up...
Growth factor signals are propagated from the cell surface, through the action of transmembrane rece...
<div><p>The cell surface is represented as a light blue rectangle and contains a variety of receptor...
Representatives shown for the MAPK, PI3K/Akt, and Wnt pathways. In the MAPK pathway, Ras gets activa...
<p>Arrows indicate stimulation, and T-bars, inhibition. EGFR-I, EGFR inhibitor; MEK, MAPK kinase.</p
The RAS-activated RAF-->MEK-->extracellular signal-regulated kinase (ERK) and phosphatidylinos...
MAP kinase signal transduction pathways are involved in many cellular processes, such as proliferati...
<p>The overall pathway by which the activation of PAR<sub>2</sub> regulates cell proliferation.</p
Growth factors and mitogens use the Ras/Raf/MEK/ERK signaling cascade to transmit signals from their...
Growth factors and mitogens use the Ras/Raf/MEK/ERK signaling cascade to transmit signals from their...
Regulation model of TYMS on cell proliferation in ESCC, arrows (→) and truncated lines (—|) indicati...
<p>(A) and (B) NIH3T3-V, -C2β-DN and -C2β-WT cells were serum-deprived overnight and stimulated for ...
<p>(A) Effect of ERK1/2 inhibitor (PD98059) on the expression of ERK1/2 and phosphor-ERK1/2. (B) Eff...
The serine/threonine kinase AKT (Protein kinase B, PKB) is a key effector of the phosphoinositide 3-...
AbstractGrowth factors and mitogens use the Ras/Raf/MEK/ERK signaling cascade to transmit signals fr...
The Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades are often activated by genetic alterations in up...
Growth factor signals are propagated from the cell surface, through the action of transmembrane rece...
<div><p>The cell surface is represented as a light blue rectangle and contains a variety of receptor...
Representatives shown for the MAPK, PI3K/Akt, and Wnt pathways. In the MAPK pathway, Ras gets activa...
<p>Arrows indicate stimulation, and T-bars, inhibition. EGFR-I, EGFR inhibitor; MEK, MAPK kinase.</p
The RAS-activated RAF-->MEK-->extracellular signal-regulated kinase (ERK) and phosphatidylinos...
MAP kinase signal transduction pathways are involved in many cellular processes, such as proliferati...
<p>The overall pathway by which the activation of PAR<sub>2</sub> regulates cell proliferation.</p
Growth factors and mitogens use the Ras/Raf/MEK/ERK signaling cascade to transmit signals from their...
Growth factors and mitogens use the Ras/Raf/MEK/ERK signaling cascade to transmit signals from their...
Regulation model of TYMS on cell proliferation in ESCC, arrows (→) and truncated lines (—|) indicati...
<p>(A) and (B) NIH3T3-V, -C2β-DN and -C2β-WT cells were serum-deprived overnight and stimulated for ...
<p>(A) Effect of ERK1/2 inhibitor (PD98059) on the expression of ERK1/2 and phosphor-ERK1/2. (B) Eff...
The serine/threonine kinase AKT (Protein kinase B, PKB) is a key effector of the phosphoinositide 3-...
AbstractGrowth factors and mitogens use the Ras/Raf/MEK/ERK signaling cascade to transmit signals fr...
The Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades are often activated by genetic alterations in up...
Growth factor signals are propagated from the cell surface, through the action of transmembrane rece...
<div><p>The cell surface is represented as a light blue rectangle and contains a variety of receptor...
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