Immunohistochemical location of TGFβ2 in the kidneys of control rats and rats fed a lithium-containing diet for 6 months.

<p>(A) Cortical region of a control rat, showing weak cytoplasmic staining in the proximal tubules but an absence of stain in the distal tubule. (B) In the outer medulla, the collecting duct is unstained but there is some staining in the thick ascending limbs. (C) In the lithium-treated animals there is strong staining in the basolateral regions of the distal tubules, but no staining in the cortical collecting ducts. (D) This pattern is repeated in the outer medulla, where the thick ascending limbs show strong basolateral staining but the collecting duct is devoid of stain. Scale bar, 50 microns.