Phylogenetic analysis and structure of FGF-associated receptors.

<p><b>A)</b> Phylogenetic analysis of selected FGF-associated receptors and Trk-associated receptors from invertebrates and vertebrates. The abbreviations are: Dan (Danio), Lot (Lottia), Apl (Aplysia), Lym (Lymnaea), Dro (Drosophila), Cap (Capitella), Cra (Crassostrea), Hom (Homo sapiens), Bra (Branchiostoma), Nem (Nematostella). The accession numbers are listed in Table 4. <b>B)</b> The extracellular domain of the Apl FGFR contains all the conserved domains associated with FGFRs, while neither Apl Nork nor Apl RRTK contains these domains. The abbreviations are: Ig, Immunoglobulin-like domain; Tyr Kinase, Tyrosine Kinase domain; LRRs, Leucine-Rich Repeats; TM, transmembrane domain; Cys-Rich, Cysteine-Rich region.