The influence of nodes degree on the empirical <i>p</i>-value [46].

<p>The top 10 genes of a random network denote the gene that rank top 10 in the random network initiated by the starting node with a specific degree. We can see that the <i>p</i>-value monotonically increases along with the increase of top 10 genes' degree and the growth rate is enhanced when initial node's degree is larger.