<div><p>Certain tumor phenomena, like metabolic heterogeneity and local stable regions of chronic hypoxia, signify a tumor’s resistance to therapy. Although recent research has shed light on the <i>intracellular</i> mechanisms of cancer metabolic reprogramming, little is known about how <i>tumors</i> become metabolically heterogeneous or chronically hypoxic, namely the initial conditions and spatiotemporal dynamics that drive these cell population conditions. To study these aspects, we developed a minimal, spatially-resolved simulation framework for modeling tissue-scale mixed populations of cells based on diffusible particles the cells consume and release, the concentrations of which determine their behavior in arbitrarily complex ways, an...
Cancer biology involves complex, dynamic interactions between cancer cells and their tissue microenv...
Cancer is a disease of cellular regulation, often initiated by genetic mutation within cells, and le...
A growing body of evidence indicates that the progression of cancer can be viewed as an eco-evolutio...
The disordered network of blood vessels that arises from tumour angiogenesis results in variations i...
Hypoxia and the pH level of the tumor microenvironment have a great impact on the treatment of tumor...
Mathematical modeling provides the predictive ability to understand the metabolic reprogramming and ...
Recent advances in molecular biology and biotechnology have helped identify novel therapeutic target...
Most of the existing mathematical models for tumour growth and tumour-induced angiogenesis neglect b...
The therapeutic control of a solid tumour depends critically on the responses of the individual cell...
A multiscale model for vascular tumour growth is presented which includes systems of ordinary differ...
Recent advances in molecular biology and biotechnology have helped identify novel therapeutic target...
Experimental evidence suggests that a tumor\u27s environment may be critical to designing successful...
Most of the existing mathematical models for tumour growth and tumour-induced angiogenesis neglect b...
In the study of cancer evolution and therapeutic strategies, scientific evidence shows that a key dy...
We present a mathematical model that describes how tumour heterogeneity evolves in a tissue slice th...
Cancer biology involves complex, dynamic interactions between cancer cells and their tissue microenv...
Cancer is a disease of cellular regulation, often initiated by genetic mutation within cells, and le...
A growing body of evidence indicates that the progression of cancer can be viewed as an eco-evolutio...
The disordered network of blood vessels that arises from tumour angiogenesis results in variations i...
Hypoxia and the pH level of the tumor microenvironment have a great impact on the treatment of tumor...
Mathematical modeling provides the predictive ability to understand the metabolic reprogramming and ...
Recent advances in molecular biology and biotechnology have helped identify novel therapeutic target...
Most of the existing mathematical models for tumour growth and tumour-induced angiogenesis neglect b...
The therapeutic control of a solid tumour depends critically on the responses of the individual cell...
A multiscale model for vascular tumour growth is presented which includes systems of ordinary differ...
Recent advances in molecular biology and biotechnology have helped identify novel therapeutic target...
Experimental evidence suggests that a tumor\u27s environment may be critical to designing successful...
Most of the existing mathematical models for tumour growth and tumour-induced angiogenesis neglect b...
In the study of cancer evolution and therapeutic strategies, scientific evidence shows that a key dy...
We present a mathematical model that describes how tumour heterogeneity evolves in a tissue slice th...
Cancer biology involves complex, dynamic interactions between cancer cells and their tissue microenv...
Cancer is a disease of cellular regulation, often initiated by genetic mutation within cells, and le...
A growing body of evidence indicates that the progression of cancer can be viewed as an eco-evolutio...