<p>Panel (a) shows time trace from the model replicating interneurons from NTG mice using mS/cm<sup>2</sup> and (b) replicates APdE9 mice using mS/cm<sup>2</sup>. <i>I</i><sub><i>stim</i></sub> = 80 pA was used in these simulations. All other parameters are as given in the text.</p
<p>Original neuron (multi-compartment HH) and synapse (NMDA+AMPA) dynamics are shown in red, the fit...
<p>Left: (Top) Raster plot of randomly chosen neurons (out of a total of neurons in the simulation...
<p>(<b>A</b> and <b>B</b>) Model responses to sustained stimulation of inhibitory neurons within the...
<p>Mean action potential amplitude (a) and maximum membrane potential during the last 200 ms window ...
<p>(a) Phase plots showing the derivative of membrane potential as a function of instantaneous membr...
<p>Membrane potential of interneurons during the last 200 ms window of the 500 ms long stimulus afte...
<p>(A) Schematic figure of the simplified model. S<sub>A</sub> and S<sub>B</sub> (on the left side) ...
The three neurons differed in their adaptation time constants (A: τq = 84.6ms, B: τq = 70.95ms, and ...
<p>A: the firing rate and the mean membrane potential. B: the synaptic conductances. The simulation ...
<p><b>A</b> Fast-spiking interneurons in layer II/III of primary somatosensory cortex were patched i...
<p><b>A</b> Recovery time after inhibition was determined by simulating an inhibitory synaptic condu...
From left to right are reported the time course of the neurotransmitter and the channel states , , ...
<p>(a) Master and Slave-Interneuron cortical-like populations. Each synaptic weight <i>g</i><sub><i>...
<p><b>A</b>. Morphology of model MSPN (not to scale). Inset: tertiary dendrites have 11 segments eac...
<p>A: The Morris water maze learning curves of mean latency time for WT and APP/PS1 mice; B: Percent...
<p>Original neuron (multi-compartment HH) and synapse (NMDA+AMPA) dynamics are shown in red, the fit...
<p>Left: (Top) Raster plot of randomly chosen neurons (out of a total of neurons in the simulation...
<p>(<b>A</b> and <b>B</b>) Model responses to sustained stimulation of inhibitory neurons within the...
<p>Mean action potential amplitude (a) and maximum membrane potential during the last 200 ms window ...
<p>(a) Phase plots showing the derivative of membrane potential as a function of instantaneous membr...
<p>Membrane potential of interneurons during the last 200 ms window of the 500 ms long stimulus afte...
<p>(A) Schematic figure of the simplified model. S<sub>A</sub> and S<sub>B</sub> (on the left side) ...
The three neurons differed in their adaptation time constants (A: τq = 84.6ms, B: τq = 70.95ms, and ...
<p>A: the firing rate and the mean membrane potential. B: the synaptic conductances. The simulation ...
<p><b>A</b> Fast-spiking interneurons in layer II/III of primary somatosensory cortex were patched i...
<p><b>A</b> Recovery time after inhibition was determined by simulating an inhibitory synaptic condu...
From left to right are reported the time course of the neurotransmitter and the channel states , , ...
<p>(a) Master and Slave-Interneuron cortical-like populations. Each synaptic weight <i>g</i><sub><i>...
<p><b>A</b>. Morphology of model MSPN (not to scale). Inset: tertiary dendrites have 11 segments eac...
<p>A: The Morris water maze learning curves of mean latency time for WT and APP/PS1 mice; B: Percent...
<p>Original neuron (multi-compartment HH) and synapse (NMDA+AMPA) dynamics are shown in red, the fit...
<p>Left: (Top) Raster plot of randomly chosen neurons (out of a total of neurons in the simulation...
<p>(<b>A</b> and <b>B</b>) Model responses to sustained stimulation of inhibitory neurons within the...
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